Approved comparison material connected to this topic.
10 total recordsSource comparisons are presented without a generated winner.
GHRP-2 GHS-R1a (ghrelin receptor) ~20 minutes 100–200 mcg subcutaneous 5–8× Moderate (3–4 weeks continuous) Hexarelin GHS-R1a ~70 minutes 6–10× High (2–3 weeks continuous) Ipamorelin GHS-R1a (selective agonist…
GHRH Analogs (CJC-1295, Sermorelin) GHRH receptor on pituitary somatotrophs Activates adenylyl cyclase → increases cAMP → opens calcium channels → GH granule release Amplifies natural pulse amplitude without c…
GHRH Analogues (CJC-1295, Sermorelin) Binds GHRH receptors on pituitary somatotrophs, triggering cAMP-mediated GH release Once daily (CJC-1295 has 6–8 day half-life; Sermorelin requires twice-daily dosing) 100…
CJC-1295 (no DAC) GHRH receptor 100–200mcg ~30 minutes 2–3x daily Short half-life requires multiple daily doses but avoids DAC's prolonged receptor desensitization. Best for mimicking natural GH pulsatility CJ…
Before selecting a peptide, compare receptor affinity, desensitisation profile, and side-effect burden across compound classes. GHRP-6 5–10× 20–30 min Moderate (3–4 weeks) High (ghrelin pathway) 2–6 weeks Acut…
CJC-1295 (with DAC) GHRH analogue. Extends natural GHRH signaling 6–8 days 30 mcg/kg or 1–2 mg fixed dose Once weekly None Best for sustained baseline GH elevation without daily injections. Ideal for hypothala…
Endogenous GH secretion follows a pulsatile pattern. Discrete bursts every 3–5 hours, with the largest pulse occurring 60–90 minutes after sleep onset. This pulsatility is critical for downstream signaling: IG…
Hexarelin Ghrelin mimetic + CD36 agonist 10-13× baseline 70 minutes 24-36 hours Moderate (some prolactin/cortisol) Highest acute GH response, cardiac research models CJC-1295 (with DAC) GHRH analog with albumi…
CJC-1295 (no DAC) Moderate (6–10 ng/mL) 30 minutes Low 12–16 weeks continuous Best for replicating endogenous pulsatility without long-term suppression. Ideal when circadian GH dynamics must remain intact CJC-…
CJC-1295 (with DAC) GHRH receptor 6–8 days 30–60 mcg/kg weekly 2–6 hours Minimal Sustained GH elevation, anti-aging models Ipamorelin GHS-R1a (ghrelin) 2 hours 200–300 mcg 2–3×/day 30–60 minutes None (highly s…